Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 164

The special centrifuge system developed by Edwin Cohn (a professor of biochemistry at Harvard who originated the plasma fractionation procedure) was modified for use as a blood processor in collaboration with the Arthur D. Little Corporation (ADL) and one of its engineers, Allan Latham, and later James Tullis, MD, a Harvard hematologist [6]. The original motivation to modify the Cohn ADL bowl was for washing and deglycerolizing previously frozen red cells. However, because of the difficulty in obtaining an adequate supply of platelets, it soon became apparent that the Latham bowl could be used to separate whole blood and collect platelets [7, 8]. Soon a free‐standing device, the Model 10, containing the centrifuge bowl, was produced by Abbott Laboratories, but they did not choose to go into the business of manufacturing medical devices.

The Cohn ADL bowl was cumbersome because the bowl itself was made of stainless steel and had many parts, all of which had to be cleaned and sterilized between uses, making it impractical for routine or large‐scale use. The centrifuge bowl system was later made from Lucite and adapted to a special centrifuge [9] that became the Haemonetics system, known as the Model 30. This system was sterile, more self‐contained, and included anticoagulant solutions, storage bags, and ancillary materials. Experience with this disposable plateletpheresis system was gained rapidly in many centers, and it became clear that a large number of platelets could be collected safely from volunteer donors [10–12].