Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 161

If a hemoglobin‐based oxygen carrier was developed, it is not likely that it will replace most red cell transfusions. The substitutes might be used for immediate restoration of oxygen delivery, such as in trauma or in other urgent situations involving massive blood loss where red cells are not available quickly, but the short intravascular half‐life of these substitutes makes them impractical for long‐term red cell replacement (for instance, in patients with chronic anemia). Because blood typing and crossmatching would not be necessary, the substitutes might be carried in emergency vehicles, stocked in emergency departments, or used by the military or civilians in situations where access to blood is limited. Other potential uses of hemoglobin substitutes include organ perfusion and preservation prior to transplantation and improving oxygen delivery to tissues that have an impaired blood supply. Unfortunately, it does not appear that a hemoglobin‐based blood substitute [24] will be available soon, and the long‐awaited “blood substitute” is not close to reality.