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In 1965, Dr. Judith Pool reported that if fresh frozen plasma was allowed to thaw at refrigerator temperatures, precipitate remained that contained most of the coagulation factor VIII from the original fresh frozen plasma [36]. This made it possible for the first time to administer large doses of factor VIII in a concentrated form to patients with hemophilia and opened an era in which the bleeding diathesis could be effectively managed. A few years later, reports began to appear describing the use of a concentrated factor VIII prepared using the plasma fractionation technique developed by Edwin Cohn [33]. This further simplified the management of hemophilia because the ability to store the factor VIII concentrates in home refrigerators enabled the development of home treatment programs involving prophylactic or immediate self‐administration of factor VIII.