Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 26

In 1926, Doan [41] described the sera of some individuals that caused agglutination of the leukocytes from others. Subsequent studies established the presence of leukocyte antibodies, the presence of these antibodies in the sera of polytransfused patients, the occurrence of white cell agglutinins in response to fetomaternal immunization, and the alloimmune and autoimmune specificities associated with these antibodies. These studies, along with studies of the murine histocompatibility system, led to the description of the major histocompatibility system (human lymphocyte antigens) [42] in humans and the understanding that there are separate antigenic specificities limited to neutrophils as well [43]. These studies also defined the causative role of leukocytes in febrile nonhemolytic transfusion reactions [44]. Strategies were sought to prevent these reactions by removing the leukocytes from blood [45, 46], one of the first methods being reported by Fleming [46], who discovered penicillin.