Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 25

The role of 2,3‐diphosphoglycerate in oxygen transport by red cells was discovered in the mid‐1960s [37, 38]. It had been known previously that this compound was better maintained at higher pH, whereas adenosine triphosphate, which appeared to be involved in red cell survival, was maintained better at a lower pH. The addition of adenine was shown to improve adenosine triphosphate maintenance and prolong red cell survival and storage for transfusion [39]. The next major advance in red cell preservation was the development of preservative solutions designed to be added after removal of most of the original anticoagulated plasma, thus further extending the storage period of red cells [40].