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Most plasma for transfusion is a by‐product of whole blood. Depending on how it is prepared, this may become fresh frozen plasma, plasma frozen within 24 hours, or cryoprecipitate‐reduced plasma (see Chapter 5). In 2017, 3,210,000 units of all plasma products were produced, and 2,318,000 (72%) were used [26]. This represents a 13.6% decrease in products and a 15% decrease in use. Cryoprecipitate production increased 16% to 2,156,000 units, but use decreased 8.5% to 1,068,000 from 2015.

Figure 2.2 Red blood cell use by hospital service in 2013. BMT, bone marrow transplantation; ER, emergency department; Hem, hematology; ICU, intensive care unit; OB/Gyn, obstetrics and gynecology; Onc, oncology.

(Source: Whitaker BI, Rajbhandary S, Harris A. The 2013 AABB blood collection, utilization, and patient blood management survey report. Bethesda, MD: American Association of Blood Banks, October 21, 2015. Reproduced with permission of AABB.)

Plasma increases might be because of production of AB plasma, which now represents a substantial portion of plasma for transfusion, probably because of changes in the management of trauma and acute blood loss (see Chapter 11).