Читать книгу Accelerated Life Testing of One-shot Devices - Narayanaswamy Balakrishnan - Страница 20

Lindsey and Ryan (1993) described experimental results conducted by National Center for Toxicological Research in 1974. 3355 out of 24 000 female mice were randomized to a control group or groups that were injected with a high dose (150 ppm) of a known carcinogen, called 2‐AAF, to different parts of the bodies. The inspection times on the mice were 12, 18, and 33 months and the outcomes of mice were death without tumor (DNT) and death with tumor (DWT), and sacrificed without tumor (SNT) and sacrificed with tumor (SWT). Balakrishnan et al. (2016a), in their analysis, ignored the information about parts of mouse bodies where the drugs were injected and combined SNT and SWT into one sacrificed group, and denoted the cause of DNT as natural death and the cause of DWT as death due to cancer. These data are summarized in Table 1.6. They then estimated the chance of death without tumor.