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1.4.7 Serial Sacrifice Data
ОглавлениеLing et al. (2020) were primarily concerned with the data (Berlin et al., 1979), presented in Table 1.7, on the presence or absence of two disease categories – (a) thymic lymphoma and/or glomerulosclerosis and (b) all other diseases – for an irradiated group of 343 female mice given ‐radiation and a control group of 361 radiation‐free female mice to study the onset time and the rate of development of radiation‐induced disease. All of the mice in both groups were sacrificed at various times, with the presence of a disease indicating that the disease onset occurred before sacrifice, while the absence of a disease indicating that the disease onset would occur after sacrifice.
Table 1.4 Failure records on grease‐based magnetorheological fluids under SSALTs with temperature (K).
Source: Zheng et al. (2018).
Stage | Inspection time (h) | Temperature | Number of samples | Number of failures |
---|---|---|---|---|
1 | 864 | 333 | 5 | 1 |
2 | 1512 | 339 | 5 | 1 |
3 | 1944 | 345 | 5 | 2 |
4 | 2160 | 351 | 5 | 2 |
Table 1.5 The number of mice sacrificed, with tumor from tumorigenecity experiments data.
Source: Kodell and Nelson (1980).
Test group | Inspection time (mo) | Sex | Dosage (ppm) | Number of mice sacrificed | Number of mice with tumor |
---|---|---|---|---|---|
1 | 9.33 | F | 60 | 72 | 1 |
2 | 14.00 | F | 60 | 48 | 3 |
3 | 18.67 | F | 60 | 36 | 18 |
4 | 9.33 | F | 120 | 48 | 0 |
5 | 14.00 | F | 120 | 47 | 14 |
6 | 18.67 | F | 120 | 26 | 25 |
7 | 9.33 | F | 200 | 47 | 4 |
8 | 14.00 | F | 200 | 45 | 38 |
9 | 9.33 | F | 400 | 24 | 16 |
10 | 14.00 | F | 400 | 10 | 9 |
11 | 9.33 | M | 120 | 48 | 0 |
12 | 14.00 | M | 120 | 44 | 7 |
13 | 18.67 | M | 120 | 42 | 11 |
14 | 9.33 | M | 200 | 47 | 3 |
15 | 14.00 | M | 200 | 32 | 5 |
16 | 18.67 | M | 200 | 19 | 8 |
17 | 9.33 | M | 400 | 24 | 0 |
18 | 14.00 | M | 400 | 22 | 11 |
19 | 18.67 | M | 400 | 15 | 11 |
Table 1.6 The number of mice sacrificed, died without tumor, and died with tumor from the ED01 experiment data.
Source: Lindsey and Ryan (1993).
Number of mice | |||||
---|---|---|---|---|---|
Test group | Inspection time (mo) | High dose of 2‐AAF | Sacrificed | Died without tumor | Died with tumor |
1 | 12 | No | 115 | 22 | 8 |
2 | 12 | Yes | 110 | 49 | 16 |
3 | 18 | No | 780 | 42 | 8 |
4 | 18 | Yes | 540 | 54 | 26 |
5 | 33 | No | 675 | 200 | 85 |
6 | 33 | Yes | 510 | 64 | 51 |
Table 1.7 Serial sacrifice data on the presence or absence of two disease categories: (a) thymic lymphoma and/or glomerulosclerosis and (b) all other diseases.
Source: Berlin et al. (1979).
Number of mice | ||||||
---|---|---|---|---|---|---|
Test group | Sacrifice time (d) | ‐radiation | Healthy | With (a) only | With (b) only | With (a) and (b) |
1 | 100 | No | 58 | 13 | 0 | 1 |
2 | 200 | No | 40 | 23 | 1 | 1 |
3 | 300 | No | 18 | 41 | 1 | 3 |
4 | 400 | No | 8 | 25 | 1 | 6 |
5 | 500 | No | 1 | 21 | 1 | 16 |
6 | 600 | No | 1 | 11 | 0 | 21 |
7 | 700 | No | 0 | 9 | 1 | 39 |
8 | 100 | Yes | 54 | 12 | 1 | 0 |
9 | 200 | Yes | 36 | 24 | 3 | 5 |
10 | 300 | Yes | 13 | 35 | 1 | 17 |
11 | 400 | Yes | 0 | 13 | 2 | 28 |
12 | 500 | Yes | 0 | 3 | 1 | 35 |
13 | 600 | Yes | 0 | 0 | 1 | 30 |
14 | 700 | Yes | 0 | 0 | 1 | 28 |