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1.4.7 Serial Sacrifice Data

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Ling et al. (2020) were primarily concerned with the data (Berlin et al., 1979), presented in Table 1.7, on the presence or absence of two disease categories – (a) thymic lymphoma and/or glomerulosclerosis and (b) all other diseases – for an irradiated group of 343 female mice given ‐radiation and a control group of 361 radiation‐free female mice to study the onset time and the rate of development of radiation‐induced disease. All of the mice in both groups were sacrificed at various times, with the presence of a disease indicating that the disease onset occurred before sacrifice, while the absence of a disease indicating that the disease onset would occur after sacrifice.

Table 1.4 Failure records on grease‐based magnetorheological fluids under SSALTs with temperature (K).

Source: Zheng et al. (2018).

Stage Inspection time (h) Temperature Number of samples Number of failures
1 864 333 5 1
2 1512 339 5 1
3 1944 345 5 2
4 2160 351 5 2

Table 1.5 The number of mice sacrificed, with tumor from tumorigenecity experiments data.

Source: Kodell and Nelson (1980).

Test group Inspection time (mo) Sex Dosage (ppm) Number of mice sacrificed Number of mice with tumor
1 9.33 F 60 72 1
2 14.00 F 60 48 3
3 18.67 F 60 36 18
4 9.33 F 120 48 0
5 14.00 F 120 47 14
6 18.67 F 120 26 25
7 9.33 F 200 47 4
8 14.00 F 200 45 38
9 9.33 F 400 24 16
10 14.00 F 400 10 9
11 9.33 M 120 48 0
12 14.00 M 120 44 7
13 18.67 M 120 42 11
14 9.33 M 200 47 3
15 14.00 M 200 32 5
16 18.67 M 200 19 8
17 9.33 M 400 24 0
18 14.00 M 400 22 11
19 18.67 M 400 15 11

Table 1.6 The number of mice sacrificed, died without tumor, and died with tumor from the ED01 experiment data.

Source: Lindsey and Ryan (1993).

Number of mice
Test group Inspection time (mo) High dose of 2‐AAF Sacrificed Died without tumor Died with tumor
1 12 No 115 22 8
2 12 Yes 110 49 16
3 18 No 780 42 8
4 18 Yes 540 54 26
5 33 No 675 200 85
6 33 Yes 510 64 51

Table 1.7 Serial sacrifice data on the presence or absence of two disease categories: (a) thymic lymphoma and/or glomerulosclerosis and (b) all other diseases.

Source: Berlin et al. (1979).

Number of mice
Test group Sacrifice time (d) ‐radiation Healthy With (a) only With (b) only With (a) and (b)
1 100 No 58 13 0 1
2 200 No 40 23 1 1
3 300 No 18 41 1 3
4 400 No 8 25 1 6
5 500 No 1 21 1 16
6 600 No 1 11 0 21
7 700 No 0 9 1 39
8 100 Yes 54 12 1 0
9 200 Yes 36 24 3 5
10 300 Yes 13 35 1 17
11 400 Yes 0 13 2 28
12 500 Yes 0 3 1 35
13 600 Yes 0 0 1 30
14 700 Yes 0 0 1 28

Accelerated Life Testing of One-shot Devices

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