Читать книгу Gastrointestinal Pathology - Группа авторов - Страница 69

EOE is initially treated with proton pump inhibitors. There is emerging evidence that PPIs affect specific inhibition of the chemokine, eotaxin, which blunts eosinophil infiltration. It may be difficult to distinguish GERD‐associated eosinophilia from EOE in this subgroup. For those that do not respond to PPI, options include identification and avoidance of food antigens (typically through a Six Food Elimination Diet; SFED) or suppression with topical corticosteroids, which can be from a swallowed metered dose inhaler, or from peroral viscous budesonide. For late‐stage, fibrotic disease, repeated, carefully monitored esophageal dilation is effective.