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Microscopic Features

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Recently proposed histologic criteria include the presence of dense lymphocytic infiltrates involving esophageal squamous mucosa with marked spongiosis in the absence of significant numbers of neutrophils or eosinophils (Figure 2.14). The findings are most pronounced in the peripapillary epithelium. There is no required or established “minimum” count or density of intraepithelial lymphocytes, and the pattern and distribution of the lymphocytic epithelial injury is most important.

Gastrointestinal Pathology

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