Читать книгу Gastrointestinal Pathology - Группа авторов - Страница 81

Sloughing esophagitis is characterized by extensive superficial squamous mucosal necrosis or desquamation, associated with endoscopic plaques imparting a sloughing appearance to the mucosa. Sloughing esophagitis has also been included under the terms esophagitis dissecans superficialis and acute necrotizing esophagitis, which includes broader inclusion criteria and more diverse causes of esophageal injury. It occurs in middle‐aged to older adults (median age 56 years), frequently with debilitating comorbidities and who are commonly on multiple medications, especially central nervous system depressants and drugs known to cause esophageal mucosal injury. It most likely represents a form of direct contact injury, rather than an ischemic injury, and may represent a unique pattern of drug‐induced esophagitis. Acute necrotizing esophagitis (“black esophagus”) is a rare condition that arises in debilitated patients with severe comorbidities such as hypoperfusion, sepsis, diabetic ketoacidosis, and malignancy, and results from the combining effect of ischemia and corrosive injury of gastric contents. A rare case occurring in a child who was associated with a history of vomiting has also been reported.