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Melanin is the major pigment accountable for skin tone and color. Due to continuous exposure, there is a sequential change in the function and structure of the skin. Due to overexposure to UV radiation, the melanin in the skin is increased due to the augmented level of tyrosinase activity. Tyrosinase is a rate‐limiting enzyme converting tyrosine to dihydroxyphenylalanine (DOPA) [67]. Further dopaquinone is converted to dopachrome with final product eumelanin leading to skin hyperpigmentation. Additionally, factors like hormonal changes signal transduction pathways also play a major role in skin pigmentation. Studies reporting the antityrosinase inhibitory activity are described using the Pleurotus species. Fruiting bodies of P. citrinopileatus species were reported for its tyrosinase activity and melanin production inhibition. Kojic acid, a low‐molecular‐weight organic acid, is widely known for its application in cosmetic and nutraceutical industries. Kojic acid is reported to be found in many fungal species with different types of substrates [68]. Due to its tyrosinase inhibition activity, kojic acid is used as an antioxidant in the cosmetic industry substituent to hydroquinone as the skin whitening agent.