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In pigs, doses of detomidine at 0.04 mg/kg IV or 0.08 mg/kg IM have been used in combination with ketamine to produce short‐term anesthesia [103]. Analgesia following lumbosacral epidural administration of detomidine was not as profound as xylazine in pigs [104]. In addition, detomidine‐ or xylazine‐induced epidural analgesia may be mediated through a different mechanism of action in that IV administration of an antagonist was capable of antagonizing epidural detomidine‐induced sedation, analgesia, and immobilization but was only able to antagonize the sedation induced by epidural xylazine but not the analgesia and immobilization [104]. This observation is supported by reports in horses and cattle [105–107]. Perhaps the difference of response to the IV administration of an antagonist lies in the fact that xylazine itself has local anesthetic effect and detomidine does not [108].