Читать книгу Farm Animal Anesthesia - Группа авторов - Страница 38

In pigs, medetomidine at IM doses of 0.03–0.08 mg/kg induced dose‐dependent sedation and muscle relaxation. Increasing the dose to greater than 0.1 mg/kg did not increase the degree of sedation or muscle relaxation but did prolong the duration of activity. Compared to 2 mg/kg of xylazine, enhanced sedation, better muscle relaxation, and greater analgesia were observed with 0.03 mg/kg of medetomidine [109]. Medetomidine has been used in combination with butorphanol (0.2 mg/kg IM) and ketamine (10 mg/kg IM) (MBK) to produce anesthesia for 98.8 ± 22.5 minutes, which is significantly longer than for a xylazine (2 mg/kg IM)–butorphanol (0.2 mg/kg IM)–ketamine (10 mg/kg IM) combination (47.5 ± 16.5 minutes). The muscle relaxation was adequate for tracheal intubation, but moderate cardiovascular depression was observed during MBK anesthesia [110]. Atipamezole effectively reversed the effects produced by 0.16–0.32 mg/kg IM of medetomidine [103].