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Red cell loss

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Collection of platelets, granulocytes, lymphocytes, or stem cells by cytapheresis results in very little red cell loss. Thus, red cell depletion is not considered a possible complication of any individual collection unless there is an instrument malfunction. However, because apheresis collections can occur with high frequency (e.g., 24 plateletpheresis collections in 12 months), cumulative red cell loss from test sampling can cause anemia and low ferritin stores [80].

Transfusion Medicine

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