Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 103

Because no more than 15% of the donor’s blood is extracorporeal at any time, there is no greater risk for blood volume shift than with whole blood donation. In addition, during apheresis, citrate and saline solutions are infused, replacing some of the lost blood volume. Thus, shifts in blood volume leading to hypotension are not a problem. Because of the administration of hydroxyethyl starch (HES) during leukapheresis as sedimenting agent, there was concern that a net increase in blood volume might occur because HES is also used as a blood volume expander. This could lead to hypertension or acute heart failure. The volume of HES administered ranges typically from 200 to 400 mL and, combined with the removal of approximately 50–200 mL of granulocyte concentrate, does not result in complications caused by excess blood volume.