Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 106

Because the HES used in granulocyte collection is a blood volume expander, some blood banks use lower blood pressure levels than those used for whole blood donors when selecting granulocyte donors. This is not a requirement, however. Granulocyte donors usually receive corticosteroids, and many also receive granulocyte colony‐stimulating factor (G‐CSF) to increase their granulocyte count and the granulocyte yield (see Chapter 6). Thus, donors should be questioned about conditions that might be exacerbated by corticosteroids. These include hypertension, peptic ulcers, cataracts, and diabetes. Because corticosteroids are given to granulocyte donors, donation frequency is limited to prevent complications. If frequent donation is required, it needs to be under the close supervision of a physician with written plans for monitoring the donor for side effects of accumulation of HES or cumulative effects of corticosteroids and/or G‐CSF.