Читать книгу Textbook of Lifestyle Medicine - Labros S. Sidossis - Страница 43

Observed metabolic disturbances during excess caloric intake are not necessarily linked to obesity.

Epidemiological data suggest that intake of energy‐dense foods (i.e., more than 225–275 kcal/100 g of food), consumers’ exposure to large serving sizes, and overeating may contribute to obesity and, therefore, increase the risk for the development of chronic diseases. Overeating has also been associated with increased aging rate and decreased lifespan. According to the “rate‐of‐living/oxidative damage” theories, lifespan extension is linked to low energy metabolism, low reactive oxygen species (ROS) production rates, low molecular damage, and slow aging. Long‐term caloric restriction studies in humans show persistent metabolic slowing accompanied by reduced oxidative stress, evidence supporting the “rate‐of‐living/oxidative damage” theories of mammalian aging.