Читать книгу Dental Management of Sleep Disorders - Ronald Attanasio - Страница 41

The main function of HA is to maintain calm wakefulness [33]. The role of HA was not known until it was recognized that antihistamines would produce sleepiness. Further investigation led to the discovery of the role of HA in the promotion of wakefulness and vigilance. It functions in a similar fashion to norepinephrine by promoting cortical activation during wakefulness. In people with narcolepsy or idiopathic hypersomnia there are low levels of HA [34]. A main source of HA in the brain is the tuberomammillary nucleus (TMN), close to the mammillary body [35]. Release of HA during NREM is minimal and there is none in REM.