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When inflammation works right, it attacks the irritant — the virus, harmful bacteria, or damaged cells. Sometimes, however, the body kicks into overdrive and launches an offensive on normal, healthy tissue. For example, if you have the autoimmune disorder rheumatoid arthritis, you see some redness and some swelling in the joints, with joint pain and stiffness. This reaction is a sign that your body is trying to attack your joint tissue, which your body mistakenly perceives as unfriendly.

Say your house is being overtaken by mosquitoes. You get some mosquito spray, light a citronella candle, and keep a rolled-up newspaper handy. You’re handling the irritant and the irritant only. Now say you’ve gone a little bit overboard. Instead of a rolled-up newspaper, you take a baseball bat and try to kill that mosquito on the wall. The problem is that the mosquito wasn’t a mosquito at all; it was just a shadow, and now you have a hole in the wall. In the same way, the immune system can overreact to perceived threats and damage the body.

The way your body responds to inflammation partially depends on your genetics and environmental factors. Most generally healthy people respond to a cut or bruise in the same way, but how the immune system responds to a virus, a bacteria, or different foods can differ from person to person. The differences in the way your immune system responds depends on the following:

 Your genes

 Factors influencing your gene expression, called epigenetics

 Your general physical and emotional state of health

 The health of major organs of immune function, such as the gastro-intestinal tract

 Your nutrient status of vitamins and minerals

 Dietary influences on health, including nutrients and toxins in food

 Environmental toxins, such as pesticides

 Blood sugar and insulin dysregulation

 Stress factors (stress weakens the immune system)

A major underlying factor in the different ways people are affected by inflammation is an imbalance in their acquired immune systems. In a healthy immune system, the helper T cells (those that are part of the immune response and attack) are in balance — one cell to attack blood-borne parasites, the other to attack invaders such as bacteria. As the immune system becomes overstimulated, the helper cells find themselves in a self-perpetuating imbalance, causing the helper cells to attack the body. As long as whatever is causing the inflammation is still present, the imbalance remains.

Inflammation can also go on too long. The innate and the acquired immune systems communicate with each other through sensors and signals, which tell the body when to release certain chemicals and proteins to activate the inflammation guard. The signals are supposed to tell the inflammation when to stop as well. That doesn’t always happen. Some people have elevated levels of C-reactive protein, an inflammatory marker that leaves the body in defensive mode, always ready to attack. When that happens, your body begins a steady downward spiral leading to disease.

Creating inflammation isn’t something your body does without effort — it takes energy, which causes fatigue and creates free radicals, molecules that cause cell damage. Thanks to all the things you’re exposed to, cells related to the inflammatory response have to become pretty strong, which means that when they attack, they do so with force. That force can cause damage the longer those cells are active.

Eating foods high in anti-inflammatory antioxidants and phytochemicals clean up the free radical damage that is associated with the immune systems’ battle. These antioxidants also help your body to detoxify and are associated with improved health and longevity.

Inflammation also causes oxidative stress and mitochondrial damage. Mitochondria are the powerhouse of a person’s cells that are needed for energy and for the system to function at its best. Besides free radical damage, inflammation can cause advanced glycation end products (AGEs) and uric acid crystals and can oxidize your bad cholesterol and other effects that unchecked can lead to chronic disease.