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Polymeric micelle (Figure 1.2c) is the class of organic nanomaterials usually formed by the spontaneous arrangement of amphiphilic block copolymers in aqueous solutions (Kulthe et al. 2012). Structurally these nanomaterials are composed of the hydrophobic core and hydrophilic shell, which facilitates the loading of various hydrophobic drugs like camptothecin, docetaxel, paclitaxel, etc. into the core to be used as nanocarriers (Singh et al. 2019). The encapsulation of drugs in polymeric micelles enhances their solubility. Various novel properties of polymeric micelles, including their small size, make them promising nanocarriers in drug delivery. Polymeric micelle‐mediated drug delivery showed many advantages like easy penetration, target‐specific drug delivery, narrow distribution to avoid fast renal excretion, etc. Moreover, polymeric micelles can also be conjugated with targeting ligands which facilitates their uptake by specific cells, thus reducing off‐target side effects. Polymeric micelles can be synthesized using two different approaches: (i) convenient solvent‐based direct dissolution of polymer followed by dialysis process; or (ii) precipitation of one block by adding a solvent (Patra et al. 2018).