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Ethosomes are also a type of phospholipid vesicles, considered a modified form of liposome mainly composed of ethanol, phospholipids, and water. In addition, some other components can also be included in ethosomes for specific characteristics e.g. polyglycol as a permeation enhancer, cholesterol to increase the stability, and dyes useful for characterization studies (Sharma 2019). These vesicles for the first time were developed by Prof. Elka Touitou around 1997. The simple synthesis process, high efficacy, and nontoxic nature of ethosomes allowed their use in widespread applications related to transdermal delivery. Ethosomes are soft, malleable vesicles tailored for enhanced delivery of active agents (Verma and Pathak 2010). Ethosomes are noninvasive delivery nanocarriers that facilitate penetration of drugs deep in the skin layers and the systemic circulation, and are reported to have higher transdermal flux than liposomes (Godin and Touitou 2003). The presence of ethanol in higher concentrations makes the ethosomes novel and unique, as ethanol is known for its disturbance of skin lipid bilayer organization.