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Polymer nanoparticles like PLGA, poly(lactic acid) (PLA), and chitosan have been used in conjugation with antihypertensive drugs for targeted and controlled drug delivery. A significant and sustained reduction in blood pressure (BP) has been recorded employing nifedipine conjugated with PLGA, PCl nanoparticles. The most important benefit of sustained release of hypertensive drugs is that it regulates BP fluctuations; also, lower doses are required compared to conventional drugs (Singh et al. 2019). Liposomal drug formulations have also been investigated using animal models for hypertension. It was observed that a single intravenous dose of liposomal formulation encapsulated with vasoactive intestinal peptide normalized BP for longer duration compared to non‐encapsulated peptide. Thus, successful conjugation of anti‐hypertensive drugs with nanoparticles increases drug circulation and also prolongs systemic availability of drugs at required concentrations (Singh et al. 2019).