Читать книгу Nanobiotechnology in Diagnosis, Drug Delivery and Treatment - Группа авторов - Страница 34

Psoriasis is a distinctive chronic inflammatory disease with a strong genetic makeup. Srisuk et al. (2012) evaluated permeability of Methotrexate (MTX)‐entrapped deformable liposomes and devised lipid vesicle from phosphatidylcholine (PC) and oleic acid (OA), and compared with MTX‐entrapped conventional liposomes synthesized using PC and cholesterol (CH) by thin‐film hydration method. MTX entrapped in PC: CH was observed to be more stable in size and loading. Although, MTX‐entrapped PC: OA liposomes increased the skin permeability characterized with higher absorption and flux of MTX diffused across or accumulated in the epidermis and dermis layers of porcine skin (Srisuk et al. 2012; Chandra et al. 2018).

Pinto et al. (2014) also developed and assessed the potential of nanostructured lipid carriers (NLCs) loaded with MTX by hot homogenization technique as a novel technique for topical therapy of psoriasis. The assessment of the in vitro skin permeation of MTX in their study showed its capability to go through the skin barrier when loaded within NLCs formulation which confirms the high potential of NLC as carriers for MTX and feasibility for topical delivery.