Читать книгу Nanobiotechnology in Diagnosis, Drug Delivery and Treatment - Группа авторов - Страница 35

To deal with HIV progression and prevent development of resistance, a combination of multiple drugs is given which is known as highly active antiretroviral therapy (HAART). Antiretroviral drugs should be able to cross the mucosal epithelial barrier when used orally. It has been reported that nanoparticles conjugated with antiretroviral drugs have the potential to target monocytes and macrophages in vitro. Poly(lactic‐co‐glycolic acid) (PLGA) nanoparticles were entrapped with three antiretroviral drugs, ritonavir, lopinavir, and efavirenz, and analyzed. It was observed that PLGA nanoparticles depicted sustained drug release for over 4 weeks (28 days), whereas the free drugs within 48 hours (2 days) (Rizvi and Saleh 2018). Thus, nanoparticles could be utilized for drug delivery of anti‐HIV drugs.