Читать книгу Nanobiotechnology in Diagnosis, Drug Delivery and Treatment - Группа авторов - Страница 32

Silica nanoparticles have been used in drug delivery applications for years, as they can be adjusted for continuous or triggered drug release (Bharti et al. 2015). Delivery of insulin across intestinal Caco‐2 cells using silica nanoparticles was reported. Silica nanoparticles, due to high surface area and selective absorption, can be extensively used in drug delivery systems (Bharti et al. 2015). Polymeric nanoparticles have been harnessed for targeted drug delivery and protection of nucleic acids. Interleukin (IL)‐10 and IL‐4 entrapped in polymeric nanoparticles were delivered to white blood cells to reduce the T cell response against native islet cells in prediabetic animal models. It was observed that the polymeric nanoparticles were useful in diabetic treatment as it inhibited the development of diabetes in 75% of the animal models (Singh et al. 2019).