Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 73

ROQUIN is a ubiquitin ligase that reportedly limits expression of Icos by binding to Icos mRNA and promoting its degradation [3]. Icos protein is critical for Tfh cell survival. The missense (M199R) sanroque mutation in the Roquin gene (Roquin^san) increases Icos expression by blocking Icos mRNA degradation [3]. Ellyard et al. reported that mice heterozygous for the Roquin^san allele exhibited dysregulated Tfh cells and develop AITL‐like tumors [4]. However, to date ROQUIN gene alterations have not been found in human AITL [5].