Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 82

Pfeifer et al. reported a PDX model in which cells from a patient with systemic CD30⁺ ALCL resistant to chemotherapy were transplanted into severe immunodeficient (SCID) mice [28]. They showed that human ALCL tumor cells xenografted and then serially passaged into SCID mice maintained the original characteristics of the patient’s tumor. This model was also used to demonstrate anti‐tumor effects of the agonistic anti‐human CD30 antibody HeFi‐1 on development of CD30⁺ ALCL tumors in mice.