Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 83

ATLL is caused by persistent infection of the human T‐cell lymphotropic virus type 1 (HTLV1). Clinical presentation of ATLL varies from relatively indolent forms to aggressive forms. ATLL develops only a small part of HTLV1 carriers after an incubation period of about 60 years from HTLV1 infection [1]. Additional genetic and epigenetic abnormalities are thought to be required for the onset of ATLL. In addition to gag, pol and env genes, the HTLV1 genome encodes accessory proteins including Tax, a transcriptional activator and HTLV1 basic leucine zipper factor (HBZ), a nuclear protein, both of which play essential roles in cellular proliferation, survival, and genetic stability of ATLL cells [29].