Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 74

AITL samples harbor recurrent somatic mutations in genes encoding epigenetic regulators such as tet methyl cytosine dioxygenase 2 (TET2), DNA methyl transferase 3 alpha and isocitrate dehydrogenase 2 [6]). All of these mutations occur frequently in numerous hematologic malignancies, whereas TET2 mutations are detected more frequently in PTCL exhibiting a TFH phenotype compared to those without a TFH phenotype [7]. The p.Gly17Val mutations in the ras homologue family member A (RHOA) (designated as the G17V RHOA mutations) are specifically found in up to 50–70% of AITL and its related lymphomas with a Tfh phenotype [6, 8, 9].