Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 77

A PDX model was established by inoculating primary AITL tumor cells and microenvironmental reactive cells into NOD/Shi‐scid, IL2Rgamma^null (NOG) mice [18]. The immunohistological features of tumors in PDX mice recapitulated those of AITL patients. Additionally, human immunoglobulin G/A/M was detected in the sera of PDX mice, indicating that patient‐derived B and plasma cells were activated by AITL tumor cells in mice. Their analysis suggests that the function of TFH cells in AITL cells was reconstituted in the PDX mice.