Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 78

Microscopically, anaplastic large‐cell lymphoma (ALCL) is commonly marked by large cells with abundant cytoplasm and eccentric, lobulated nuclei [1]. CD30 is highly expressed on the surface of ALCL cells [1]. ALCL is classified in two distinct diseases by the expression of ALK: ALCL, ALK positive and ALCL, ALK negative. The translocations involving ALK gene with various partner genes are essential mechanisms in ALK‐positive ALC. The most frequent translocation, t(2;5)(p23; q35), fuses a portion of the nucleophosmin (NPM)1 gene on chromosome 5q35 with a portion of ALK on chromosome 2p23 [1]. The NPM1‐ALK fusion gives rise to a chimeric protein consisting of the NPM1 N‐terminus with the ALK catalytic domain [19].