Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 85

Xenograft mouse models transplanted with ATLL patient‐derived cells have been examined [40]. In these models, immunodeficient SCID and NOD/SCID recipient mice displayed multiple features of human ATLL disease, namely, aberrant lymphocyte infiltration in liver, spleen, lung, peritoneum, and other organs. These models have helped define mechanisms underlying HTLV1 infection, clonal proliferation and the immune response against HTLV1 and have contributed to development of targeted therapies. For example, treatments using the antibody against C─C chemokine receptor type 4 and an inhibitor of histone deacetylase have been tested in these models.