Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 81

In 2019, Rajan et al. used gene editing to establish a mouse model of ALCL, ALK+ after transplantation of hematopoietic stem cells with Npm1‐Alk generated by a CRISPR‐Cas9 method [27]. The lymphoma cells had a large‐cell morphology with CD30 expression accompanied by oligoclonal TCR rearrangements. These features were compatible with those of ALK‐positive ALCL. Therefore, this method may replace traditional approaches to modeling of ALCL in mice.