Читать книгу Advances in Radiation Therapy - Группа авторов - Страница 12

Historically, one of the first systematic approaches to immunotherapy for cancer was therapy with induced erysipelas performed by William Coley [1]. Inoculation of bacteria (Streptococcus pyogenes) locally at the tumour site when followed by signs of local and systemic infection led to tumour shrinkage and in some patients to complete and lasting responses of inoperable cancers [2]. The mixture of heat-inactivated Streptococci and heat inactivated Serratia became known as “Coley’s toxin” [3].