Читать книгу Textbook of Lifestyle Medicine - Labros S. Sidossis - Страница 48

Industrially produced but not naturally occurring TFAs are associated with increased risk of CHD.

Another mechanism through which high TFA consumption can add to the CVD risk is by increasing inflammation and endothelial dysfunction. Data from the Nurses' Health Study I (NHS‐I) have shown that women who were free of CVD, cancer, and diabetes at baseline and who consumed a diet high in TFAs were more likely to have increased levels of inflammation and endothelial dysfunction. The positive relationship between TFA intake and systemic inflammation was also evident in an NHS‐II cohort; a modest mitigation of this association after controlling for serum lipid levels led to the hypothesis that TFAs impact on serum lipids may act as mediator of this positive association. In 2018, the WHO published an action package to reduce TFA use in the global food supply called the “REPLACE action package.” Based on a six‐step strategy, each country should implement actions to eliminate the industrially produced TFAs.