Читать книгу Primary Care for COMLEX Level 1 - Dr. Jahan Eftekar - Страница 17

Myasthenia Gravis

•20-30 year-old female

•Thymic hyperplasia

•Eaton-Lambert myasthenia

•Motor end-plate acetylcholine receptor antibody

•Fatigue on exertion

•Swallowing and ocular muscles problems

•Symptoms worse at night

•Improves with edrophonium

Duchenne Muscular Dystrophy

•Dystrophin deficiency

•X-linked

•Calves pseudohypertrophy

•Creatine-phosphokinase

Becker Muscular Dystrophy

•X-linked

•Better prognosis than Duchenne

•Walking through mid 20’s

Rheumatoid Arthritis

•Rheumatoid factor

•Pannus

•Proximal interphalangeal joints

•Symmetric arthritis

•HLA antigen

•Felty’s syndrome

Gout

•Hyperuricemia

•Tophi

•Monosodium urate crystals in joints

•Uric acid stones

•Metatarsophalangeal joint

Osteosarcoma

•Malignant

•Adolescence

•Codman’s triangle

•Metaphysis

•Retinoblastoma

•Chromosome 13, deletion 14

Chondrosarcoma

•Pelvis

•Mostly older adult males

•Malignant

Ewing’s Sarcoma

•Diaphysis

•Skull metastasis

•Soft tissue penetration

•Pelvis and long bones

•Young male Caucasian (< 15)

•Resembles osteomyelitis

•“Onion skin”

Paget’s Bone Disease

•Increased osteoblastic and osteoclastic activities

•Tibial bowing

•Mosaic bone

•Increased serum phosphatase

•High output cardiac failure

•Increased risk of osteosarcoma

Ankylosing Spondylitis

•Spine sacroiliac joint

•HLA-B27

•Young male

•Aortic insufficiency

•Iritis