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CNS Keyboard Associations

•Syphilis ⇔ Tabes dorsalis

•Rabies ⇔ Negri body

•Epidural hematoma ⇔ Middle meningeal

•Subdural hematoma ⇔ Bridging veins tear

•Berry aneurysm ⇔ Subarachnoidal hemorrhage

•Cerebral infarct ⇔ Middle cerebral artery

•Anencephaly ⇔ α-fetoprotein

•Pituitary tumor ⇔ bitemporal hemianopsia

•Toxoplasmosis ⇔ Placental infection

•Lacunar infarct ⇔ Thalamus

•Creutzfeldt-Jacob ⇔ Rapidly progressive dementia

•Progressive multifocal leukoencephalopathy ⇔ Measles, AIDS

•Meningioma ⇔ Psammoma bodies, Palisading

•Alzheimer’s ⇔ Neurofibrillary tangles, β2 Amyloid, most common

•Pick’s disease ⇔ Pick’s bodies

•Guillain-Barré syndrome ⇔ Acute peripheral neuritis

•Multiple Sclerosis ⇔ HLA haplotypes

•Parkinson’s ⇔ Substantia nigra, Lewy bodies, L-dopa, Resting tremor

•Toxoplasmosis ⇔ Transplacental

•Viral meningoencephalitis ⇔ Perivascular cuffing, glial inclusion bodies

•Poliomyelitis ⇔ Necrosis of anterior horn of spinal cord

•Idiopathic Parkinson’s ⇔ Paralysis agitans, Lewy bodies, L-dopa

•Von Economo’s encephalitis ⇔ Post-encephalitis Parkinsonism

•Shy-Dragger Syndrome ⇔ Parkinsonism plus autonomic disorder

•Cytomegalovirus ⇔ Giant cells with eosinophilic bodies

•Kuru ⇔ Cannibalism, spongiosis

•Subacute sclerosing panencephalitis ⇔ measles

•Progressive Multifocal leukoencephaly ⇔ Papovavirus

Pyogenic Meningitis

•E. Coli, infants

•H. Influenzae, Children

•N. Meningitidis, adolescence

Multiple Sclerosis

•Increased CSF immunoglobulin

•HLA haplotypes

•Paraventricular plaques

•Helper CD4+ and cytotoxic CD8+ T lymphocytic infiltration

•IgM antibody = recent primary infection

Alzheimer’s

•Progressive dementia

•Choline acetyltransferase deficiency

•Alteration of nucleus basalis of Meynert

Parkinson’s

•Substantia nigra

•Lewy bodies

•L-dopa

•Resting tremor

•Rigidity

•Bradykinesia

•Mask-like facies

Huntington’s Disease

•Atrophy of caudate nucleus

•Atrophy of Putnam

•Chromosome 4

•Delay of clinical abnormalities until 30-40 years of age

Medulloblastomas

•Young children

•Cerebellum

•Rosette or perivascular pseudo-rosette pattern