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The cosmetically relevant and noticeable changes in aging skin are (i) hyper‐pigmentation or age spots, (ii) wrinkled and saggy skin, (iii) dryness and dull skin tone, (iv) thin and injury‐prone skin [18]. All the above‐mentioned changes in an individual arise due to the interplay of intrinsic and extrinsic factors. Mechanistic insights of various intrinsic and extrinsic factors involved in skin aging are summarized in Figure 4.2. In the present section, we will explore the details of these factors, and we will try to touch their mechanisms.