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Intrinsic factors are the combination of various physiological, biochemical, and genetic changes that an individual undergoes during its lifespan. An overall reduction in the thickness of aging skin is attributed to the progressive decline in the dermal and epidermal cellular ability to divide and proliferate over time. Thus, a decline in the number of keratinocytes and fibroblasts will reduce skin's elastin and collagen level causing it to become thin and saggy [19].