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The microbial products are of utmost importance because of their versatility, and there are multiple reasons behind it, viz., easy culturing, infinite production, the end product being eco‐friendly, and nontoxic [44]. When it comes to cosmetics, any product with applicable effectiveness remains in high demand and usage on one of the sensitive and environmentally exposed human organ skin, which is also of a socio and psychological concern for the human being that makes it even more effective. However, the skin is a multilayer organ consisting of differentiated cells playing different functions associated with defense, skin color, sensation, prevention of water loss, and structural integrity; therefore, it is crucial to have formulations that do not interfere with other structures and mechanisms. Pharmaceutical ingredients that are practiced currently in the market are being utilized beyond its capacity, and hence at multiple levels, it reveals certain side effects because of synthetic and chemical nature, while microbial products have got the advantage over it having nontoxic nature [45]. As we know, culturing microbes is conventional and easy on a large scale nowadays due to automated specifically designed fermenter machines, which keeps optimized conditions for the entire production cycle. Therefore, biological products have got the ease of adaptation to the human body and environment as they possess organic nature and comparatively fewer side effects. Another parameter associated with the benefit of using microbial products is they can be modified according to physicochemical requirements and optimized according to physicochemical needs, for example, usage of several enzymes into textile and detergent industries [45]. However, it can be applicable for enzymatic activities, but similar studies support the modification of microbial products and enhancements of physicochemical properties of active compounds under different conditions. For example, the production of keratinase enzyme by Bacillus subtilis and production of rhamnolipids by Pseudomonas aeruginosa where keratinase enzyme remains active molecule produced by microbes to utilize keratin from surrounding, and rhamnolipid remains secondary metabolite secreted to enhance surface activity to enhance adherence and proliferation/differentiation of skin cells [46, 47]. Cosmetics require multiple formulations for specific applications like powder, ointment, face wash, skin lightening, cleansing, hair removing, smoothening, moistening, etc., so suitable selection of microbial product and its effectiveness under chemical formulation is a crucial task to project future of the formulated product and its long‐lasting effectiveness.