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Aging, in many ways, affects organellar efficiency. Mitochondria, which is regarded as the powerhouse of the cell, also maintains a fine balance of ROS and antioxidants in the cell. A dysfunctional mitochondria arising due to mutations or ROS damage increases the propensity of oxidative stress in the cell, thereby increasing the damage [27]. Mitochondrial dysfunction associated senescence (MiDAS) is one of the major intrinsic factors involved in skin aging [28, 29].