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The fact that skin cells lose their regenerative ability after several divisions are associated with a phenomenon known as “Hayflick's Limit,” and was proposed by Leonard Hayflick and colleagues [11]. According to him, somatic cells have a finite proliferative ability, which can be extrapolated to predict the lifespan of any species. Mechanistic insights into Hayflick's limit theory was described independently by Watson and Olovnikov in the 1970s. According to them, “telomere” being the terminal portion of linear eukaryotic genome gets shortened progressively upon successive cellular division, and cell ceases to divide further upon reaching a threshold [20, 21].

Figure 4.2 Various intrinsic and extrinsic skin aging factors.