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ISCOMs are biomolecular structures. They are made up of cholesterols, phospholipids, and Quil A saponins. ISCOMs have an immunostimulatory effect because they contain Quil A saponins, which are well-known adjuvants. ISCOMs have been studied for around 35 years to be highly effective as a synthetic vaccine [88]. Still, they can cause significant, unfavorable injection-site reactions [89], limiting their use to animal vaccinations [90]. ISCOMA-TRIX is identical to the traditional ISCOM except that the Quil A saponins are first filtered to give a specified group of saponins that do not induce substantial inflammation [91]. ISCOMA-TRIX has been demonstrated to produce immune responses in mice and rabbits [92].