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The Peripheral T-Cell Lymphomas
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Страница 1
Table of Contents
List of Tables
List of Illustrations
Guide
Pages
The Peripheral T‐Cell Lymphomas
Страница 8
Contributors
About the Companion Website
Страница 11
1 The Fundamentals of T‐cell Lymphocyte Biology
TAKE HOME MESSAGES
Introduction
General View of the Differentiation and Function of T Lymphocytes
The T‐cell System as a Frame for Peripheral T‐cell Lymphoma: Taking Plasticity into Account
Must Reads
References
2 Mechanisms of T‐cell Lymphomagenesis
TAKE HOME MESSAGES
Introduction
Oncogenic Events in the Transformation of T or Natural Killer Cells Genetic Lesions
Deregulated Pathways in Peripheral T‐cell Lymphoma Oncogenesis (
Figure 2.1
,
Table 2.1
) Epigenetic Regulation
Signaling Pathways
Cell‐cycle Control
Immune Surveillance
Role of the Microenvironment in Peripheral T‐cell Lymphoma
The Model of Angio‐immunoblastic T‐cell Lymphoma and T Follicular Helper‐derived Peripheral T‐cell Lymphoma
Crosstalk Between Neoplastic T Follicular Helper Cells and Their Microenvironment in Angioimmunoblastic T‐cell Lymphoma
Genetic Alterations in the Angioimmunoblastic T‐cell Lymphoma Microenvironment
Specific Microenvironment Components Present in Other Primary Cutaneous T‐cell Lymphoma Entities
Macrophages
Angiogenesis
Eosinophils
Underlying Factors Favoring the Tumor Transformation
Viruses
Human T‐cell Leukemia Virus Type 1
Epstein–Barr Virus
Chronic Antigenic Stimulation
Other Factors
Cell of Origin (
Table 2.1
)
Conclusion
Acknowledgement
Must Reads
References
3 Epigenetics of T‐cell Lymphoma
TAKE HOME MESSAGES
Introduction
Epigenetic Pathways Altered in T‐cell Lymphoma
Epigenetic Changes Within Specific T‐cell Lymphoma Subtypes
Peripheral T‐cell Lymphoma Not Otherwise Specified
Angioimmunoblastic T‐cell Lymphoma and Peripheral T‐cell Lymphoma with T Follicular Helper Phenotype
Anaplastic Large‐cell Lymphoma
Adult T‐cell Leukemia/Lymphoma
Intestinal T‐cell Lymphoma
Hepatosplenic T‐cell Lymphomas
Extranodal Natural Killer/T‐cell Lymphoma
Mycosis Fungoides and Sézary Syndrome
Established and Emerging Drugs Targeting the T‐cell Lymphoma Epigenome
DNA Methyltransferase Inhibitors
Isocitrate Dehydrogenase Inhibitors
EZH2 Inhibitors
BET Inhibitors
Protein Arginine Methyltransferases Inhibitors
Combination Therapies Involving Epigenetic Targeting Agents
Future Directions
Must Reads
References
4 Animal Models of T‐cell Lymphoma
TAKE HOME MESSAGES
Introduction
Angioimmunoblastic T‐cell Lymphoma
The ROQUIN Mouse Model
The Mouse Models Recapitulating Human Angioimmunoblastic T‐cell Lymphoma Genomic Features
Tet2 Gene Trap Mice
G17V RHOA Mouse Model
PDX Models of Angioimmunoblastic T‐cell Lymphoma
Anaplastic Large T‐cell Lymphoma
Viral and Chimeric Models
Transgenic Models
CRISPR‐Based Models
PDX Models of Anaplastic Large‐Cell Lymphomas
Human T‐cell Lymphotropic Virus Type 1 Adult T‐cell Leukemia/Lymphoma
Mice Expressing HTLV‐1 Viral Proteins
PDX Models of Adult T‐cell Leukemia/Lymphoma
Cutaneous T‐cell Lymphoma
Enteropathy‐associated T‐cell Lymphoma
Conclusion
Must Reads
References
Страница 91
5 Geographic Distribution of the Peripheral T‐cell Lymphomas: Global Epidemiology
TAKE HOME MESSAGES
Historical Perspective
Epidemiology
Peripheral T‐cell Lymphoma, Not Otherwise Specified
Angioimmunoblastic T‐cell Lymphoma
Anaplastic Large‐cell Lymphoma
Adult T‐cell Lymphoma/Leukemia(HTLV Associated)
Extranodal NK/T‐cell Lymphomas
T‐cell Prolymphocytic Leukemia
Large Granular Lymphocytic Leukemia
Primary Cutaneous Gamma/Delta PTCL
Enteropathy Associated T‐cell Lymphomas and Monomorphic Epitheliotropic Intestinal T‐cell lymphoma
Hepatosplenic T‐cell Lymphoma
The Cutaneous T‐cell Lymphomas
Conclusion
Must Reads
References
5.A 2017 World Health Organization Classification of Mature T- and NK-cell Neoplasms
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